‘ Fatigue in myasthenia gravis : Is it more than muscular weakness ? ’ 1 2
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Exercise prescription in the physiotherapeutic management of Myasthenia Gravis: a case report
INTRODUCTION Myasthenia Gravis (MG), a slowly progressive neuromuscular disorder, can be classified as either ocular or generalised. MG affects between 5 – 12 people per 100,000 (Muscular Dystrophy Association, 2004).Ocular involvement is often the fi rst sign of MG with patients complaining of ptosis and diplopia. Seventy-fi ve to ninety percent of patients with ocular involvement then progres...
متن کاملUsefulness of single fiber EMG for distinguishing neuromuscular from other causes of ocular muscle weakness.
Consecutive patients (n = 114), who had single fiber electromyography of the frontalis muscles for symptoms suggestive of ocular myasthenia gravis, were followed up for a mean of 14 months (3-64 mos). At follow up, based on strict criteria, 23 patients were classified as having ocular myasthenia gravis, 8 patients were diagnosed as having mitochondrial myopathy or oculopharyngeal dystrophy, 18 ...
متن کاملBreathing pattern and central ventilatory drive in mild and moderate generalised myasthenia gravis.
BACKGROUND Myasthenia gravis is a specific autoimmune disease characterised by weakness and fatigue. Respiratory muscle weakness has been studied using the determination of maximal respiratory pressures, but the response of respiratory centres is not well characterised. This study was undertaken to determine the breathing pattern and the central ventilatory drive in patients with mild and moder...
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Congenital Myasthenic Syndromes (CMS) are rare inherited disorders characterized by dysfunction of neuromuscular transmission at the neuromuscular junction. Most patients with congenital myasthenic syndromes present in the infancy. Major symptoms of affected individuals include weakness and fatigue during the first years of life. Patients may show hypotonia, facial weakness, swallowing difficul...
متن کاملExperimental myasthenia gravis. A murine system
Mice from eight inbred strains were immunized with acetylcholine receptor (AChR) purified from Torpedo californica. All mice developed high concentrations of serum antibodies (10(-6) M) against the immunogen and approximately 80% possessed antibodies reactive with mouse nicotinic AChR. 33% of the mice immunized (n = 236) developed muscular weakness and flaccid paralysis. Behavioral, electrophys...
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